Chorionic Villus Sampling: Results of 135 High Risk Cases 

İskender BAŞER, Sadettin GÜNGÖR, Ali ERGÜN

Ankara-Turkey

OBJECTIVE: To assess the data related to the first-trimester chorionic villus sampling performed in a single tertiary center.

STUDY DESIGN: Transabdominal CVS performed on 135 pregnant women, aged 18 to 38 years, at 11 to 14 weeks’ gestation, who sought prenatal diagnosis for various reasons, during the years 2000-2004. Procedure related fetal loss rate, the indications, results of cytogenetic analysis and the clinical outcomes of patients was obtained retrospectively.

RESULTS: The indications for prenatal diagnosis were enzymatic/DNA analysis for single gene defects (31.1%), advanced positive screening test result (22.2%), advanced maternal age (17.8%), and maternal anxiety (11.9%). Karyotyping was totally successful and chromosomal abnormality was detected in 3 women (2.2%). The procedure related fetal loss rate was 0.0%.

CONCLUSION: CVS performed 11-14 weeks of gestation by experienced operators is a quick, reliable, and safe diagnostic method for prenatal diagnosis and the overall incidence of antenatal and neonatal complications is no greater than that expected for a general population.

(Gynecol Obstet Reprod Med 2006; 12:000-000)

Key Words: Prenatal diagnosis, Chorionic villus sampling, Transabdominal, First-trimester, Outcome