Treatment of Non - Complicated Lower Urinary Tract Infection in Pregnancy: Single Dose Fosfomycin Tromethamine Versus Multiple Dose Nitrofurantoin Murat ÖZEL, Oktay KAYMAK, Nüvit BİRGİLİ, Şevki ÇELEN, Mine ERDOĞAN, Nuri DANIŞMAN Ankara, Turkey OBJECTIVE: To evaluate the efficacy of single-dose fosfomycin tromethamine (FT) treatment in pregnant women with uncomplicated lower urinary tract infection (UTI). STUDY DESIGN: In this study, 421 pregnant women with established, symptomatic, uncomplicated lower UTI were randomly allocated to receive either a single dose of FT (Monurol®, Zambon Group S.p.A, Milan-ITALY) (n=217) or a 7-day course of nitrofurantoin (n=204). The treatment was found to be effective if urine culture was negative 15 days after therapy. RESULTS: Microbiological cure was achieved in 205 (94.5%) patients treated with FT and 164 (80.4%) patients treated with nitrofurantoin (p<0.05). Pathogen microorganisms were predominantly E.coli (199 in FT and 183 in NF group) followed by Klebsiella (18 in FT and 21 in NF group). CONCLUSION: The treatment of acut lower UTI in pregnant women is essential. FT is an effective, safe, single dose treatment choice in the management of uncomplicated lower UTI in pregnant women. Key Words: Urinary tract infections, Pregnancy, Fosfomycin tromethamine, Nitrofurantoin
Treatment of Non - Complicated Lower Urinary Tract Infection in Pregnancy: Single Dose Fosfomycin Tromethamine Versus Multiple Dose Nitrofurantoin Murat ÖZEL, Oktay KAYMAK, Nüvit BİRGİLİ, Şevki ÇELEN, Mine ERDOĞAN, Nuri DANIŞMAN Ankara, Turkey
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