Two Different Regimens of Intravaginal Plus Oral and
Intravaginal Misoprostol for Termination of
Second Trimester Pathologic Pregnancies

C. Eftal TANER, Ümit NAYKI, Afet EGE, Tolga MIZRAK
İzmir-Turkey

OBJECTİVE: To compare the safety and efficacy of two different regimens of misoprostol for termination of second trimester pathologic pregnancies.
MATERİALS AND METHODS: 150 women with 14-28 weeks gestations and with indications of termination of their pregnancies were enrolled. 89 women (Group A) were administered two intravaginal tablets and continued to oral half tablet in every two hours unless active contractions began. 61 pregnants (Group B) were administered one intravaginally tablet and continued to one intravaginal tablet in every three hours. Procedures were repeated up to five times.
RESULTS: There were no significant differences in clinical properties of the groups. In Group A patients total dose was significantly higher than Group B (1251.6 versus 806.4 mcg). There were no significant difference in induction labor intervals (13.6 versus 11.9 hours) and failure rates (16.8% versus 13.1%) side effects were similar except on uterine rupture in Group A in a case with a previous cesarean section.
CONCLUSİON: Both intravaginal plus oral and intravaginal administrations of misoprostol can be accepted as efficient and safe, but pregnants with previous cesarean sections should intensively be followed.
(Gynecol Obstet Reprod Med 2005; 11:31-33)

Key Words: Misoprostol, Termination of pregnancies