Comparision of Vaginal Metronidazole with Vaginal Clindamycin for the
Treatment of Bacterial Vaginosis in Women Using Intrauterine Devices

Reyhan NESLİHANOĞLU, Ahmet Cantuğ ÇALIŞKAN, Ertan AKPINAR, Alptekin ALAGÖZ,
Sertaç BATIOĞLU, Leyla MOLLAMAHMUTOĞLU
Tokat-Turkey

OBJECTIVE: To examine the efficacy of clindamycin vaginal cream and vaginal metronadizole for the treatment of bacterial vaginosis in intrauterin device users.
STUDY DESİGN: 66 women with bacterial vaginosis using intrauterin device were assigned to receive either 2% clindamycin vaginal cream or metronidazole vaginal tablet for 7 days. Quantitative vaginal cultures for bacterial vaginosis were performed at enrollment and at 4-7 days and 30 days after completion of therapy.
RESULTS: Of the 66 patients using intrauterin device enrolled, 19 (61%) of 31 were cured with clindamycin, compared with 21 (60%) of 35 were cured with metronidazole at 30 days. No significant difference was observed between the treatment groups in the incidence of adverse events.
CONCLUSION: Clindamycin 2% vaginal cream offers similar efficacy to vaginal metronidazole administration for treatment of bacterial vaginosis in women using intrauterin devices.
(Gynecol Obstet Reprod Med 2005; 11:107-109)

Key Words: Bacterial Vaginosis, Intrauterin Device, Clindamycin, Metronidazole