Prognostic Factors in Uterine Cervix Adenocarcinoma

Hasan BOZKAYA, Mehmet A. OSMANAĞAOĞLU, Selen OSMANAĞAOĞLU, Barış VURALLI
Trabzon-Turkey

To review the prognostic factors in uterine cervix adenocarcinoma In this retrospective study, we identified studies which were obtained from a medline search from 1987 through 2004 and published in the English language regarding prognostic factors influencing survival and recurrences in cervical adenocarcinoma. Clinicopathological prognostic factors, including patient age, clinical stage, tumor histopathology, lymph node metastasis, grade, tumor size, the depth of tumor invasion, lymphovascular space invasion, angiogenesis and molecular prognostic factors, including DNA flow cytometry, DNA content, estrogen and progesteron receptors, p53, VEGF, interleukin-8, tumour necrosis factor-?, and platelet-derived endothelial cell growth factor, cyclooxygenase-2, ß-catenin, mitotic index/apoptotic index, c-erbB-2 and proliferating cell nuclear antigen labelling index, Bcl-2, caspases, CA-125 were investigated. In many studies using a wide variety of clinicopathological factors and tumor markers have been analyzed as potential prognostic predictors in patients with cervical adenocarcinoma. Unfortunately, the results of these studies are in part fragmentary and such of little practical value. Further long-term studies are required to analyze the efficiency, different types of prognostic factors.
(Gynecol Obstet Reprod Med 2005; 11:218-223)

Key Words: Adenocarcinoma of the uterine cervix, Prognostic factors