The Distribution of The Lumbal Bone Mineral Density Within Turkish Postmenopousal Female Population

Gültekin KÖSE, Murat APİ, Nurettin AKA

İstanbul-Turkey

OBJECTIVE: The aim of this study was to evaluate the distribution of the lumbal bone mineral density within Turkish postmenauposal female population. Models proposed so far for pathogenesis of osteoporosis often do not take the factors underlying the different incidences of vertebral fractures in different location in the spinal column and in different populations.

STUDY DESIGN: To adress this issue, we analyzed 580 postmenopausal female patients in a population-based retrospective study. Bone mineral density (BMD) values found at the lumbal spine were almost similar. Intraclass Correlation Coefficient (ICC) was computed for L1, L2, l3, L4, L2-4. Two-way mixed effect model (ConsistencyDefinition) defined as people effect random and measure effect fixed. Single Measure Intraclass correlation was foun to be 0.9068.

RESULTS: The same estimator is used whether the interaction effect is present or not. (95% C.I. Lower=0.8850, Upper=0.9260, F=49.6643, p<0.0001) Cronbach alpha reliability anlaysis showed the mean vertebral t scores-1.33 (min:-1.45 and max:-1.15 and inret-item correlations mean r=0.9 8min :0.82 and max :0.97).

CONCLUSION: Estimated marginal means of measure revealed L3 vertebra is the most reliable  amongst the others and can be used single most effective diagnostic marker in postmenouposal female Turkish patients. These results confirm the associaton of BMD in lumbal spines and support the evidence that lumbal bone density measurements play a significant role in the diagnosis of osteoporosis  and L3 is the best predictive parameter among those tested.

(Gynecol Obstet Reprod Med 2006; 12:000-000)

Key Words: Vertebral BMD, Turkish population, Osteoporosis