ÖZET

Amaç: Osteoporoz (OP) ve ateroskleroz (AS) arasındaki ilişki günümüzde büyük ilgi uyandırmaktadır. Biz de ça­lış­mamızda; postmenopozal OP ile koroner arter hastalığı (KAH) ve Framingham kalp çalışmasında elde edilen KAH riski arasında ilişki olup olmadığını araştırmayı amaçladık.
Gereç ve Yöntem: Yüz on yedi postmenopozal bayan olgu DEXA yöntemi ile belirlenen kemik mineral dan­si­to­met­ri (KMD) skorlarına göre; herhangi bir bölgedeki T skoru <-2.5 olanlar osteoporozlu, (-1.0)-(-2.5) arasında o­lan­lar os-teo­penik ve >-1.0 olanlar normal kabul edilmek üzere 3 gruba ayrıldı. Olgulardan KAH hikayesi bulunanlar be­lir­le­nir-ken, KAH bulunmayan olgular ise Framingham kalp çalışmasında kullanılan formülle elde edilen KAH risk skor­larına gö­re; 0-10 arasında olanlar, 10-20 arasında olanlar ve 20 üzerinde olanlar olmak üzere 3 ayrı grupta in­ce­lendi.
Bulgular: KAH sıklığı, OP’si (n=28, %51.9) olanlarda, osteopenik (n=14, %31.8) veya normallerle (n=4, %21.1) kı­yas­landığında daha yüksek idi (sırasıyla p=0.04 and p=0.02). OP’si olanların 7 (%26.9)’sinde, osteopenisi olanların i­se 3’ünde (%10) KAH risk skoru >20 idi. KAH riski >20 olan normal olgu yoktu. KAH risk skoruna göre OP’si olan ol­gularla osteopenik ve normal olgular arasında istatistiksel olarak anlamlı fark vardı (sırasıyla p=0.02, p=0.01 ).
Sonuç: Çalışmamızda postmenopozal kadınlarda OP-KAH, riski arasında anlamlı ilişki saptadık.
Anahtar Kelimeler: Osteoporoz, Koroner, Risk

Osteoporosis-Coronary Artery Disease-Framingham Coronary Artery Disease Risk Score
Correlation in Postmenopausal Women

SUMMARY

Objective: Relationship between osteoporosis (OP) and atherosclerosis (AS) is in great interest. In our study, we ai­med to show whether there is a relationship between coronary artery disease (CAD), the heart risk score ob­ta­i­ned by the formula that is used in Framingham heart study, and postmenopausal OP or not.
Material and Methods: According to bone mineral density, 117 postmenopausal patients were divided into 3 gro­ups. First group of patients who had T score <-2.5 was accepted as osteoporotic, second group who had T sco­re between -1.0 and -2.5 was accepted as osteopenic, third group who had T score >-1.0 was accepted as normal. Firstly, patients with CAD were determined. Then, patients with no CAD were divided into 3 different groups ac­cor­ding to Framingham CAD risk scores. The score of first group was < 10, second group was between 10 and 20, last group was >20.
Results: The frequency of CAD of osteoporotic patients (n=28, 51.9%) was higher than the osteopenic patients (n=14, 31.8%) or normals (n=4, 21.1%), (p=0.04 and p=0.02 respectively). Patients having normal BMD score did not have CAD risk score >20. Three (10%) osteopenic patients had CAD risk score >20. Seven (26.9%) os­teo­po­ro­tic patients had CAD risk score >20. According to CAD risk score, there was significantly difference between pa­ti­ents with OP and patients with osteopenia or normal (p=0.02, p=0.01, respectively).
Conclusions: In our study, we demonstrated the CAD-OP correlation and OP-Framingham CAD risk score cor­re­la­tion directly in postmenopausal women.
Key Words: Osteoporosis, Coronary, Risk