ÖZET

Hiperviskozite sendromunun en sık sebebi olan monoklonal hipergamaglobulinemi multipl myeloma ve makroglobulinemide görülür. Hiperviskozite semptomlarını bünyesel semptomlar, kanama, oküler, nörolojik ve kardiovasküler bulgular oluşturur. Hiperviskozitenin acil tedavisi plazmaferez ile kan viskozitesinin düşürülmesine yönelik olmalıdır.
Anahtar Kelimeler: Hiperviskozite sendromu, Makroglobulinemi, Multipl myeloma

Hyperviscosity Syndrome in Plasma Cell Dyscrasias

SUMMARY

Monoclonal hypergammaglobulinemia which is the most common cause of hyperviscosity syndrome is seen in multiple myeloma and Waldenström’s Macroglobulinemia.Symptoms of hyperviscosity include constitutional symptoms, bleeding, ocular, neurological, and cardiovascular manifestations.Immediate therapy of symptomatic hyperviscosity is directed at reduction of blood viscosity by plasmapheresis.
Key Words: Hyperviscosity syndrome, Waldenström’s macroglobulinemia, Multiple Myeloma