Helicobacter Pylori Positivity in Patients with Hyperemesis Gravidarum
Emel Ebru ÖZÇİMEN1, Ayla ÜÇKUYU1, Işık ÜSTÜNER1, Filiz Fatma YANIK2,
Sevsen KULAKSIZOĞLU3, Mesut ÖKTEM2, Derya EROĞLU2, Esra KUŞÇU2
Konya-Turkey
OBJECTIVE: To investigate the relationship between Helicobacter pylori (H. pylori) infection and hyperemesis gravidarum (HG) by using H. pylori specific serum antibody test and H. pylori stool antigen (HpSA).
MATERIAL AND METHODS: This prospective cross-sectional study was carried out on 70 pregnant women with HG and 70 healthy pregnant women. Serum immunoglobulin G antibody for H. pylori and HpSA were assayed in both groups. Chi-square test was used for statistical analysis.
RESULTS: The study and control groups were matched regarding the maternal age, gestational weeks, gravida and parity. Positive serum IgG concentrations were found in 35 of the 70 HG patients (50%) compared with 33 of 70 controls (47.1%), (p>0.05). The rate of HpSA positivity was 32.8% (23/70) and 21.4% (15/70) respectively (p>0.05).
CONCLUSION: Contradicting with most of the studies which investigated the relationship between H. pylori infection and HG, our results indicate no significant relationship between HG and H. pylori IgG and HpSA.
(Gynecol Obstet Reprod Med 2006; 12:165-168)
Key Words: Helicobacter pylori, Hyperemesis gravidarum, Helicobacter pylori stool antigen, Helicobacter pylori seropositivity
